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Study on the neurological mechanism of different factors [4] Chinnakkaruppan Adaikkan, Steven J.Middleton,
of visible light radiation (color temperature, frequency, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys,
modulation mode, radiation intensity). The significance David Nam-Woo Kim, FanGao, Jennie Z.Young,
of light in biological evolution is self-evident, yet its Ho-Jun Suk,Edward S.Boyden,Thomas J.McHugh,
molecular mechanism is still quite unclear, especially the Li-HueiTsai, “Gamma Entrainment Binds Higher-
mechanism of the direct effect of the light on the nervous Order Brain Regions and Offers Neuroprotection”,
system. One can continue to carry out mouse experiments Neuron 102, 929–943 June 5, 2019
on this platform to accumulate more knowledge in this
area. It is anticipated that successful implementation of [5] World Health Organization: Group Interpersonal
this work into the human medical applications will open Therapy (IPT) for Depression, 2016:
a new field for human recognition. https://www.who.int/mental_health/mhgap/interpers
onal_therapy/en/
There is no doubt ICT technology could play a much more
important role with the combination of the non-intrusive [6] Cui Zhe, Hao Luoxi, Xu Junli, “A Study on the
optical intervention therapy by introducing an adaptive Emotional and Visual Influence of the CICU
feedback mechanism through artificial intelligence, machine Luminous Environment on Patients and Nurses”,
learning and other methods. The therapeutic effect can be Journal of Asian Architecture and Building
tracked and the treatment process and intensity can be Engineering, 2017
flexibly adjusted to further enhance the effectiveness. Other
than that, there might be another advantage by conducting [7] World Health Organization, Mental health of older
this research. As visible light communication is considered adults. December 2017:
as a promising technology for indoor applications, it is also https://www.who.int/en/news-room/fact-
necessary to evaluate the potential impact from the low- sheets/detail/mental-health-of-older-adults
frequency operation of LED in VLC application on human
wellness. Therefore, it is quite important to consider and [8] ITU-R REPORTS
coordinate standardization efforts from the perspectives of Visible light for broadband communications:
communication, Internet of light application, and the non- https://www.itu.int/pub/R-REP-SM.2422
intrusive optical intervention therapy.
[9] J. Cosmas, Y. Zhang and X. Zhang, "Internet of
6. ACKNOWLEDGEMENT Radio-Light: 5G Broadband in Buildings," European
Wireless 2017; 23th European Wireless Conference,
The authors would like to thank Dr. Wei Shi for her great Dresden, Germany, 2017, pp. 1-6.[10]
help in arranging mouse experiments. This work was Strategic Roadmap 2025 of the European
supported by the National Key Research and Development Lighting Industry:
Program of China (2017YFB0403402) and also by the https://www.lightingeurope.org/images/160404-
Natural Science Foundation of Guangdong Province (Grant LightingEurope_Roadmap---final-version.pdf
No. 2015A030312006).
[11] openbci website: https://openbci.com/
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