Page 41 - ITU KALEIDOSCOPE, ATLANTA 2019

ICT for Health: Networks, standards and innovation

the correspondence between the behavioral model of the
mouse and the acquired signals should be carefully aligned.
Since the anatomy of the mouse brain region is quite clear,
we focus on the visual cortex, the rhythm control brain
region and the hippocampus which is responsible for
memory. The mice with Alzheimer’s disease will be
observed by dissection after the experiment, and whether the
symptoms were alleviated (i.e., whether the amyloid
deposition in the brain has been significantly reduced).

After many repetitive and more accurate experiments on
mice in the future, more experimental data of various visible
light signal constellation and modulation formats commonly
used in the visible light communications systems, light color
temperature, lighting frequency, continuous irradiation time
and other factors will be obtained for the comparative
analysis and clear conclusions can be drawn with greater
confidence. Based on this analysis, an experimental model
can be eventually established and this will pave the way, or
at least lay down the foundations, for future initial human
trials.
5. CONCLUSION AND FUTURE WORK

This paper introduces the basic concept, system architecture
and schematic diagram of the main functional modules of the
IoL network based on the combination of lighting LED and
ICT technology for indoor applications. With this
infrastructure, the concept of the non-intrusive optical
intervention therapy is proposed to support regulating the
human physiological rhythm while maintaining its main
Figure 6 - Results of local field potential signal analysis in illumination functionality. The related research plan has
the hippocampal area of mice been designed and carried out through a mouse experiment
to see the impact of the visible light irradiation on mice. The
feasibility of this idea is conceptually proved from the
4. DISCUSSIONS preliminary experimental results which could bring a new
paradigm of treatments for nursing homes. In the future, we
From this preliminary experiment, it is proved that the will further explore the possibilities from the following
hippocampus of mice, in charge of learning and memory is aspects with the help of current medical research progress on
responsive to visible light modulation. From one side, it degenerative diseases:
suggests that in a realistic lighting environment, appropriate
modulation methods could be utilized to help prevent, relieve 1 Treatment of Alzheimer's disease
and treat some human diseases associated with this function.
On the other hand, certain measures should be taken to Combining more experiments on mice with advanced
reduce the possible negative impact of lighting on human
health if visible light communications with different signal intelligent analysis, and also considering the combining
effect of other traditional therapy. People can gradually
waveforms are used in conjunction with illumination
purposes for the indoor environment. explore the possibilities of reducing or removing
Alzheimer's disease symptoms by this non-intrusive
treatment on human beings, especially for the elderly in
The experiment is to let normal mice and mice with nursing homes.
Alzheimer’s disease exposed to visible light with the similar
lighting environment as that for the human brain to observe
the behavior, rhythm and memory changes of those mice 2 Regulation of depression
under an LED light source operating at different operating
frequencies (mainly concerned about 20Hz ~ 50Hz), Designing and conducting the experiments on mice to
different color temperatures and different constellation and confirm the effectiveness of alleviating depressive
modulation methods. The EEG signals were obtained by symptoms by adjusting the parameters such as color
electrodes mounted outside the mouse's skull, and the temperature and intensity. The experimental treatment
electrical signals of their specific brain regions were for the elderly can then be carried out in nursing homes.
recorded by in-vivo patch clamps and other
electrophysiological techniques. When recording the data, 3 Explain how light and the nervous system interacts

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