This Recommendation provides the framework and requirements of machine learning based end-to-end network slice management and orchestration in multi-domain environments. It addresses the following subjects: Overview and interoperability requirements of machine learning based multi-domain end-to-end network slice management and orchestration; Functional requirements of machine learning based multi-domain end-to-end network slice management and orchestration; Framework of machine learning based multi-domain end-to-end network slice management and orchestration; Cognitive components for the framework.