Data has become one of the most important assets in ICT area. Secure multi-party computation (MPC) could build trust and security in data collaboration and big data analysis related areas by balancing data usage and data protection. This recommendation specifies technical guidelines for MPC and provides a technical standard basis for ICT stakeholders to use MPC to protect data in data collaboration and big data analysis scenarios. It also describes applications where MPC can be used for and how as a reference for ICT stakeholders to develop MPC applications. The content of the Recommendation includes: Technical framework of MPC: defines the elements in MPC and the workflow between the elements; Security levels of MPC protocols: analyse and define the security model and threshold; Applications of MPC: describe a few use cases of MPC, including application scenario description, processes, etc, with respective recommendation on security requirements. Based on the framework and security levels established in this recommendation, standards for MPC applications in different fields can be defined.