Recommendation ITU-T X.b2m allows a medical centre remotely to monitor a patient and to retrieve information from that patient. It defines a general protocol for exchange of biometric information from a patient facility to a medical expert facility. It also allows the medical expert facility to control the sensors and other devices at the patient facility and to establish the environment for a monitor session at the patient facility. It also defines a versatile and open-ended information model that allows any type of medical and non-medical information to be transferred. Recommendation ITU-T X.b2m is a biosignal communication protocol between computing devices and biological systems. X.b2m protocol is based upon an aggregation of the interactions between a computing device and the biological system. Biometric interactions are described using the telebiometric multimodal model as defined by [ITU-T X.1081], which is a three-layer model combining the sciences, sensors, and metric layers. X.b2m is a horizontal market protocol designed to be used for all IoT biometric metric applications i.e. aerospace, medical, automotive, industrial and consumer markets. For the case of clinical medical trials, X.b2m protocol enriches the application with a versatile and open-ended information model filled with interaction descriptions thereby ensuring an accurate comparison of measurement processes.